Rubric condition met: Meta-analyses of randomized placebo-controlled trials with a consistent direction for power; small studies, mostly men
An NIH-funded individual participant data meta-analysis of 19 double-blind crossover studies (268 participants) found higher maximal muscle power (g = 0.42, about 5%), and a 2025 umbrella review found higher peak power output (SMD 0.25). The effect on maximal strength was trivial (SMD 0.08), peak power and peak velocity in squat and bench press did not change significantly, and a 2026 athlete meta-analysis found no significant pooled effect on any of its six outcomes. Most participants were men.
How sure are we?
Evidence maturity: Emerging Meta-analyses of many RCTs from many independent groups (Coggan 2021 individual-participant meta-analysis (19 studies, 268 participants)); Established once a preregistered independent RCT is confirmed.
The small-studies check (B5) on per-trial sizes is not complete; the B grade stands until it is.
Tested as: Dietary nitrate dosed in mmol (concentrated beetroot juice or sodium nitrate)
Who paid for the studies
Mixed
Risk of bias
Some concerns
Trial registry check
Not checked yet
Outcome measured
A test score, rating scale or performance measure
Who was studied
Matched
Doses used in studies
About 5 mmol nitrate (roughly 310 mg) per dose or more
Rules applied
B5: small studies (logged, no further change): Trial sizes could not be confirmed from the abstracts
Could rise: Would move to A with resolution of the A rule (the null athlete and pooled analyses explained by dose or training status in a preregistered analysis) plus at least one large independent preregistered RCT.
Could fall: Would move to C if B5 is confirmed (every supporting RCT under 40 participants), or if a preregistered adequately sized RCT were null in recreationally active adults.
Science is provisional. This grade reflects the evidence we found as of . Next review: .
Maturity sits beside each grade. The grade says what the evidence shows; maturity says how much of it there is and how well it is confirmed.
Established
many trials from several independent teams, including at least one registered in advance
Emerging
two or more trials, or one large registered trial, not yet independently confirmed
Early signal
one trial, small pilots, or results only on secondary outcomes
Mechanistic only
lab, animal or biomarker data, or uncontrolled reports; no controlled human results
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.Show the numbers
Study
Year
Design
Participants
Result
Coggan 2021
2021
meta-analysis
268
result not recorded
Alvares 2022
2022
meta-analysis
not recorded
result not recorded
Tan 2023
2023
meta-analysis
not recorded
result not recorded
Poon 2025
2025
umbrella review
2672
result not recorded
Xie 2026
2026
meta-analysis
659
result not recorded
Effects of Dietary Nitrate Supplementation on Back Squat and Bench Press Performance: A Systematic Review and Meta-Analysis.
Tan R, Pennell A, Karl ST. Effects of Dietary Nitrate Supplementation on Back Squat and Bench Press Performance: A Systematic Review and Meta-Analysis Nutrients, 2023. PMID 37299456
Result not recorded
Design
Systematic review and meta-analysis of 6 studies
Population
Resistance-trained adult men
Funding
not stated in the PubMed or Crossref record; full text not read
Effect of dietary nitrate ingestion on muscular performance: a systematic review and meta-analysis of randomized controlled trials.
Alvares TS, Oliveira GV, Volino-Souza M. Effect of dietary nitrate ingestion on muscular performance: a systematic review and meta-analysis of randomized controlled trials Crit Rev Food Sci Nutr, 2022. PMID 33554654
Result not recorded
Design
Systematic review and meta-analysis of 34 randomized controlled trials
Population
Adults in resistance-exercise trials
Funding
FAPERJ, NSERC, Heart and Stroke Foundation of Canada (Crossref funder list)
Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis.
Coggan AR, Baranauskas MN, Hinrichs RJ. Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis J Int Soc Sports Nutr, 2021. PMID 34625064
Result not recorded
Design
Systematic review and individual participant data meta-analysis of 19 randomized, double-blind, placebo-controlled crossover studies
Sample
n = 268
Population
Adults (218 men, 50 women)
Funding
US National Institute on Aging (R21 AG053606) and NCATS (UL1 TR002529)
Dietary Nitrate Supplementation and Exercise Performance in Athletes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Xie Y, Han Y, Du Q. Dietary Nitrate Supplementation and Exercise Performance in Athletes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Sports (Basel), 2026. PMID 42931603
Result not recorded
Design
Systematic review and meta-analysis of 45 randomized, placebo-controlled trials
Sample
n = 659
Population
Healthy athletes (Tier 2 or higher)
Funding
not stated in the PubMed or Crossref record; full text not read
Dietary Nitrate Supplementation and Exercise Performance: An Umbrella Review of 20 Published Systematic Reviews with Meta-analyses.
Poon ET, Iu JC, Sum WM. Dietary Nitrate Supplementation and Exercise Performance: An Umbrella Review of 20 Published Systematic Reviews with Meta-analyses Sports Med, 2025. PMID 40085422
Result not recorded
Design
Umbrella review with meta-analysis of 20 systematic reviews (180 primary studies)
Sample
n = 2,672
Population
Participants in placebo-controlled exercise trials
Funding
No specific grant (stated in the paper)
Search and history
Search (): (nitrate[ti] OR beetroot[ti]) AND (strength[tiab] OR power[tiab] OR sprint*[tiab]) AND (meta-analysis[pt])
Graded B (awaiting approval)
B to B (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page
B to B (approved) (maturity: emerging): Maturity, bias summary and re-check date added
A, strong: what grade A means
At least one meta-analysis or three independent randomized trials in the relevant healthy population, pointing the same way, with low or some risk of bias, at doses legally available.