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Celastrus paniculatus and mood: grade D

Preliminary evidence. Direction: No effect.

D Preliminary

Educational guidance, not medical advice

Why this grade

Rubric condition met: No controlled human outcome data; animal studies only

Reviews list antidepressant-like activity from animal work, and one mouse study tested the seed oil alone and with a prescription antidepressant after chronic stress. No study measured mood in people. As of November 11, 2026 we found no controlled human trial of Celastrus paniculatus on mood (PubMed and Europe PMC searches, 2026-11-11).

How we grade evidence

Studies this grade rests on

EffectMixedNo effectSize shows participants (n)202020252030Animal study (mic…Narrative reviewChahuan 2023, 2023: animal study (mice, chronic unpredictable stress), alone and with fluoxetine, n not recorded, result not recordedNagpal 2022, 2022: narrative review, n not recorded, result not recorded
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.
Show the numbers
StudyYearDesignParticipantsResult
Nagpal 20222022narrative reviewnot recordedresult not recorded
Chahuan 20232023animal study (mice, chronic unpredictable stress), alone and with fluoxetinenot recordedresult not recorded

Amelioration of modified chronic unpredictable stress using Celastrus paniculatus seed oil alone and in combination with fluoxetine.

Chahuan S, Grover S, Singh S. Amelioration of modified chronic unpredictable stress using Celastrus paniculatus seed oil alone and in combination with fluoxetine Drug Chem Toxicol, 2023. PMID 35943180

Result not recorded
Design
Animal study (mice, chronic unpredictable stress), alone and with fluoxetine
Population
Mice (animal model)
Funding
not stated in the PubMed or Crossref record; full text not read

An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd.

Nagpal K, Garg M, Arora D. An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd Phytother Res, 2022. PMID 35199395

Result not recorded
Design
Narrative review
Population
Published phytochemical and pharmacological literature
Funding
not stated in the PubMed or Crossref record; full text not read

Search and history

Search (): (Celastrus paniculatus[tiab] OR jyotishmati[tiab]) AND (anxiety[tiab] OR stress[tiab] OR mood[tiab] OR sleep[tiab])

  • Graded D (proposed): Proposed in the monograph draft
  • D to D (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page