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Celastrus paniculatus and perceived stress: grade D

Preliminary evidence. Direction: No effect.

D Preliminary

Educational guidance, not medical advice

Why this grade

Rubric condition met: No controlled human outcome data; one registered trial protocol with no results; animal studies only

The only human study of Celastrus paniculatus alone that we found is a published protocol for a 70-person trial comparing Celastrus seed powder with a prescription anxiety medicine in generalized anxiety disorder (a clinical population); no results were found. Stress findings come from rats under restraint stress and mice under chronic unpredictable stress. As of November 11, 2026 we found no completed controlled human trial on stress (PubMed and Europe PMC searches, 2026-11-11).

How we grade evidence

Studies this grade rests on

EffectMixedNo effectSize shows participants (n)201520202025RCTAnimal study (mic…Animal study (rat…Gamne 2023, 2023: RCT, n = 70, result not recordedChahuan 2023, 2023: animal study (mice, chronic unpredictable stress), alone and with fluoxetine, n not recorded, result not recordedBhagya 2016, 2016: animal study (rats, chronic restraint stress), n not recorded, result not recorded
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.
Show the numbers
StudyYearDesignParticipantsResult
Bhagya 20162016animal study (rats, chronic restraint stress)not recordedresult not recorded
Chahuan 20232023animal study (mice, chronic unpredictable stress), alone and with fluoxetinenot recordedresult not recorded
Gamne 20232023RCT70result not recorded

Amelioration of modified chronic unpredictable stress using Celastrus paniculatus seed oil alone and in combination with fluoxetine.

Chahuan S, Grover S, Singh S. Amelioration of modified chronic unpredictable stress using Celastrus paniculatus seed oil alone and in combination with fluoxetine Drug Chem Toxicol, 2023. PMID 35943180

Result not recorded
Design
Animal study (mice, chronic unpredictable stress), alone and with fluoxetine
Population
Mice (animal model)
Funding
not stated in the PubMed or Crossref record; full text not read

Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment.

Bhagya V, Christofer T, Shankaranarayana Rao BS. Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment Indian J Pharmacol, 2016. PMID 28066108

Result not recorded
Design
Animal study (rats, chronic restraint stress)
Population
Rats (animal model)
Funding
not stated in the PubMed or Crossref record; full text not read

Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial.

Gamne R, Misar S, Rai M. Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial F1000Res, 2023. PMID 39114320

Result not recorded
Design
Protocol for a randomized, active-controlled, double-blind equivalence trial (no results published)
Sample
n = 70
Population
Planned: adults aged 20-50 with generalized anxiety disorder, mild to moderate (clinical population)
Funding
Central Council for Research in Ayurveda Sciences (CCRAS), Ministry of AYUSH, Government of India, grant STAR/283/7 (stated in the paper)

Search and history

Search (): (Celastrus paniculatus[tiab] OR jyotishmati[tiab]) AND (anxiety[tiab] OR stress[tiab] OR mood[tiab] OR sleep[tiab])

  • Graded D (proposed): Proposed in the monograph draft
  • D to D (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page