Limited evidence. Direction: No effect.
C Limited
Rubric condition met: The rubric cap: clinical-only evidence (hypertension, cardiometabolic disorders); conflicting meta-analyses, so direction none
A 2016 Cochrane review pooled 2 RCTs (50 participants) with primary hypertension and found no significant change, rating this moderate-quality evidence of no clinically significant effect. A 2022 meta-analysis of 26 studies in cardiometabolic disorders found systolic pressure fell by 4.77 mmHg, while a 2026 meta-analysis of 20 RCTs in prediabetes and type 2 diabetes found no significant effect. The larger falls in a 2007 meta-analysis rest on before-after comparisons and open-label studies. No trials in people with normal blood pressure are cited.
| Study | Year | Design | Participants | Result |
|---|---|---|---|---|
| Rosenfeldt 2007 | 2007 | meta-analysis | 362 | result not recorded |
| Ho 2016 | 2016 | meta-analysis | 50 | result not recorded |
| Zhao 2022 | 2022 | meta-analysis | 1831 | result not recorded |
| Rezagholizadeh 2026 | 2026 | meta-analysis | not recorded | result not recorded |
Rosenfeldt FL, Haas SJ, Krum H. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials J Hum Hypertens, 2007. PMID 17287847
Rezagholizadeh F, Rezvani S, Oskouie FH. The effect of CoQ10 supplementation on cardiovascular risk factors in patients with prediabetes and type 2 diabetes mellitus: a grade-assessed systematic review and dose-response meta-analysis BMC Pharmacol Toxicol, 2026. PMID 42642774
Zhao D, Liang Y, Dai S. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials Adv Nutr, 2022. PMID 36130103
Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension Cochrane Database Syst Rev, 2016. PMID 26935713
Search (): (coenzyme Q10[ti] OR CoQ10[ti] OR ubiquinol[ti]) AND (blood pressure[tiab] OR hypertension[tiab]) AND (meta-analysis[pt] OR systematic review[pt])
