Limited evidence. Direction: Benefit.
C Limited
Rubric condition met: The rubric cap: pooled estimates from clinical or undescribed populations with no healthy-only estimate (C)
A 2024 meta-analysis of 12 studies (489 subjects) found flow-mediated dilation rose with CoQ10 (WMD 1.45) in a dose-related way, and a 2012 meta-analysis of 5 RCTs (194 patients with and without cardiovascular disease) found improved flow-mediated dilation but no change in nitrate-mediated dilation. Neither abstract gives a healthy-adult estimate, so the grade is capped at C.
| Study | Year | Design | Participants | Result |
|---|---|---|---|---|
| Gao 2012 | 2012 | meta-analysis | 194 | result not recorded |
| Daei 2024 | 2024 | meta-analysis | 489 | result not recorded |
Gao L, Mao Q, Cao J. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials Atherosclerosis, 2012. PMID 22088605
Daei S, Ildarabadi A, Goodarzi S. Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials High Blood Press Cardiovasc Prev, 2024. PMID 38630421
Search (): (coenzyme Q10[ti] OR CoQ10[ti] OR ubiquinol[ti]) AND (endothelial function[tiab] OR flow-mediated[tiab]) AND (meta-analysis[pt] OR systematic review[pt])
