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Panax ginseng and endurance performance: grade N

No benefit shown evidence. Direction: No effect.

N No benefit shown

Why this grade

Rubric condition met: N: adequate human RCTs and two meta-analyses found no meaningful effect

A meta-analysis of eight placebo-controlled RCTs found no effect on physical performance (SMD -0.01). A 2022 meta-analysis of 14 studies in athletes and active people found no effect on most measures, with one isolated vertical-jump result at high doses whose reported effect size is implausible. Placebo-controlled trials of 200-400 mg a day for 3-8 weeks found no change in aerobic capacity, and a review of red ginseng trials found no aerobic improvement. NCCIH (T2) agrees.

How we grade evidence

Studies this grade rests on

EffectMixedNo effectSize shows participants (n)1995200020052010201520202025Meta-analysisSystematic reviewRCTBach 2016, 2016: meta-analysis, n = 630, result not recordedEngels 1997, 1997: RCT, n = 36, result not recordedAllen 1998, 1998: RCT, n = 28, result not recordedLee 2016, 2016: systematic review, n not recorded, result not recordedKhan 2022, 2022: meta-analysis, n not recorded, result not recorded
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.
Show the numbers
StudyYearDesignParticipantsResult
Engels 19971997RCT36result not recorded
Allen 19981998RCT28result not recorded
Lee 20162016systematic reviewnot recordedresult not recorded
Bach 20162016meta-analysis630result not recorded
Khan 20222022meta-analysisnot recordedresult not recorded

Red Ginseng as an Ergogenic Aid: A Systematic Review of Clinical Trials.

Lee NH, Jung HC, Lee S. Red Ginseng as an Ergogenic Aid: A Systematic Review of Clinical Trials J Exerc Nutrition Biochem, 2016. PMID 28150477

Result not recorded
Design
Systematic review of 14 clinical trials
Population
Exercising adults (red ginseng)
Funding
not stated in PubMed or Crossref records

No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise.

Engels HJ, Wirth JC. No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise J Am Diet Assoc, 1997. PMID 9336557

Result not recorded
Design
Randomized, double-blind, placebo-controlled trial (8 weeks)
Sample
n = 36
Population
Healthy men (31 completed)
Funding
not stated in PubMed or Crossref records

Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance.

Allen JD, McLung J, Nelson AG. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance J Am Coll Nutr, 1998. PMID 9791844

Result not recorded
Design
Randomized, double-blind, placebo-controlled trial (3 weeks)
Sample
n = 28
Population
Healthy young adults (20 men, 8 women)
Funding
not stated in PubMed or Crossref records

Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis.

Khan N, Sharma S, Dahiya I. Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis J Sports Sci, 2022. PMID 36604650

Result not recorded
Design
Systematic review and meta-analysis of 14 studies
Population
Athletes and active participants
Funding
No funding (Crossref funder statement)

Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis.

Bach HV, Kim J, Myung SK. Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis J Korean Med Sci, 2016. PMID 27822924

Result not recorded
Design
Meta-analysis of 12 placebo-controlled RCTs
Sample
n = 630
Population
Adults in RCTs of fatigue or physical performance
Funding
National Cancer Center, Korea (Crossref funder list)

Search and history

Search (): ginseng[ti] AND (exercise[tiab] OR physical performance[tiab] OR ergogenic[tiab]) AND (meta-analysis[pt] OR systematic review[pt] OR review[pt])

  • Graded N (proposed): Proposed in the monograph draft
  • N to N (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page