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Taurine and blood pressure: grade C

Limited evidence. Direction: Benefit.

C Limited

Educational guidance, not medical advice

Why this grade

Rubric condition met: Pooled estimates that mix healthy and clinical populations, with no healthy-only effect size or trial count reported; not B because no the rubric path is met in the relevant population: the healthy subgroup is reported only as significant, and the 120-person RCT enrolled people with prehypertension and does not state its funding

Four meta-analyses (7 to 34 trials) found lower systolic and diastolic blood pressure with taurine than with control, by about 3 to 4.38 mmHg systolic on average; two of them come from the same research group and report the same systolic estimate. The 2018 and 2024 analyses mix healthy people with people who have heart or other conditions, and the 2026 abstract does not describe its trial populations. A 2024 meta-analysis reported a significant systolic reduction in its healthy-individual subgroup. A double-blind, placebo-controlled 12-week trial in 120 adults with prehypertension found larger clinic and 24-hour reductions with 1.6 g/day than with placebo. Because the pooled estimates mix populations and the healthy subgroup is reported without an effect size or trial count, the grade is capped at C.

How we grade evidence

Studies this grade rests on

EffectMixedNo effectSize shows participants (n)2015202020252030Meta-analysisRCTTzang 2024, 2024: meta-analysis, n = 1,024, result not recordedTzang 2024, 2024: meta-analysis, n = 808, result not recordedSun 2016, 2016: RCT, n = 120, result not recordedWaldron 2018, 2018: meta-analysis, n = 103, result not recordedNie 2026, 2026: meta-analysis, n not recorded, result not recorded
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.
Show the numbers
StudyYearDesignParticipantsResult
Sun 20162016RCT120result not recorded
Waldron 20182018meta-analysis103result not recorded
Tzang 20242024meta-analysis1024result not recorded
Tzang 20242024meta-analysis808result not recorded
Nie 20262026meta-analysisnot recordedresult not recorded

Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.

Tzang CC, Chi LY, Lin LH. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials Nutr Diabetes, 2024. PMID 38755142

Result not recorded
Design
Systematic review and meta-analysis of 25 RCTs
Sample
n = 1,024
Population
Adults in trials of metabolic syndrome-related measures
Funding
Ministry of Science and Technology, Taiwan, Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 106-2314-B-002-180-MY3 and MOST 109-2314-B-002-114-MY3, National Taiwan University Hospital, Bei-Hu Branch National Science and Technology, Taiwan

Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.

Nie Z, Liu Y, Zhang M. Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials Nutr Rev, 2026. PMID 41275513

Result not recorded
Design
Systematic review and meta-analysis of 34 RCTs
Population
Adults in cardiometabolic risk factor trials
Funding
Scientific Research Foundation for Scholars 2022QDL004, Scientific Research Foundation for Scholars of HZNU, Scientific Research Foundation for Scholars of HZNU 2022QDL004

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.

Sun Q, Wang B, Li Y. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study Hypertension, 2016. PMID 26781281

Result not recorded
Design
Randomized, double-blind, placebo-controlled trial, 12 weeks
Sample
n = 120
Population
Adults with prehypertension
Funding
not stated

Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.

Tzang CC, Lin WC, Lin LH. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis Nutr J, 2024. PMID 39148075

Result not recorded
Design
Systematic review and meta-analysis of 20 RCTs
Sample
n = 808
Population
Healthy people and people with heart failure, hypertension or other diseases (mixed populations)
Funding
Ministry of Science and Technology, Taiwan, Ministry of Science and Technology, Taiwan MOST 106-2314-B-002-180-MY3 and MOST 109-2314-B-002-114-MY3, National Science and Technology, Taiwan, National Science and Technology, Taiwan NSTC 112-2314-B-002-134, National Taiwan University Hospital, Bei-Hu Branch

The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.

Waldron M, Patterson SD, Tallent J. The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis Curr Hypertens Rep, 2018. PMID 30006901

Result not recorded
Design
Meta-analysis of 7 studies
Sample
n = 103
Population
Humans of varying age and health status
Funding
not stated

Search and history

Search (): taurine[ti] AND (blood pressure[tiab] OR hypertension[tiab]) AND (meta-analysis[pt] OR systematic review[pt])

  • Graded C (proposed): Proposed in the monograph draft
  • C to C (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page