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Taurine and endurance performance: grade B

Moderate evidence. Direction: Benefit.

B ModerateShort-term only

Why this grade

Rubric condition met: Meta-analysis with high heterogeneity; not A because certainty was rated low to very low and no meta-analysis is confirmed independent

A 2018 meta-analysis of 10 studies of isolated oral taurine found improved endurance performance (Hedges' g = 0.40), with no difference between single doses and courses of up to 2 weeks. A 2025 meta-analysis of 23 randomized trials with 308 participants found a smaller overall performance effect (g = 0.25, I2 = 61%) and rated certainty low to very low, with prediction intervals that often included no effect. Ref 2's endurance signal is a moderator result, and the authors report that several subgroup effects weakened after influential studies were excluded. B is kept because ref 1 is an endurance-specific meta-analysis of isolated taurine with a confidence interval that excludes no effect, and ref 2's pooled estimate points the same way (G2); the low certainty is stated on the page. Trials used single doses or courses of up to 2 weeks, so the short-term modifier applies. Funding for both meta-analyses is not stated.

How we grade evidence

Studies this grade rests on

EffectMixedNo effectSize shows participants (n)2015202020252030Meta-analysisSystematic reviewDeng 2025, 2025: meta-analysis, n = 308, result not recordedChen 2021, 2021: systematic review, n not recorded, result not recordedWaldron 2018, 2018: meta-analysis, n not recorded, result not recorded
each study this grade rests on, by publication year and design. Solid: effect versus the comparator; half-filled: mixed; hollow: no effect; dashed: result not recorded yet. Larger marks had more participants.
Show the numbers
StudyYearDesignParticipantsResult
Waldron 20182018meta-analysisnot recordedresult not recorded
Chen 20212021systematic reviewnot recordedresult not recorded
Deng 20252025meta-analysis308result not recorded

The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review.

Chen Q, Li Z, Pinho RA. The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review Front Physiol, 2021. PMID 34497536

Result not recorded
Design
Systematic review of 10 articles
Population
Adults in aerobic and strength exercise studies
Funding
not stated

Does One Shot Work? The Acute Impact of a Single Taurine Dose on Exercise Performance: A Meta-Analytic Review.

Deng H, Song T, Yin M. Does One Shot Work? The Acute Impact of a Single Taurine Dose on Exercise Performance: A Meta-Analytic Review Scand J Med Sci Sports, 2025. PMID 40852891

Result not recorded
Design
Systematic review and three-level meta-analysis of 23 randomized trials (k = 69)
Sample
n = 308
Population
Adults in exercise performance trials (single acute dose)
Funding
not stated

The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.

Waldron M, Patterson SD, Tallent J. The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis Sports Med, 2018. PMID 29546641

Result not recorded
Design
Meta-analysis of 10 studies (isolated oral taurine)
Population
Range of human subjects in endurance exercise trials
Funding
not stated

Search and history

Search (): taurine[ti] AND (exercise[tiab] OR performance[tiab] OR endurance[tiab]) AND (meta-analysis[pt] OR systematic review[pt])

  • Graded B (proposed): Proposed in the monograph draft
  • B to B (approved): Editor sign-off November 13, 2026: grade matches the editor-approved final page