What is ashwagandha? A plain-English guide
Ashwagandha is a plant used in Ayurvedic medicine. One review found it lowered stress scores versus a dummy pill; another found no clear effect. A sleep review found a small improvement, larger in adults with insomnia. Product makers funded or supplied some key trials. Rare liver injury has been reported; Australia's regulator warns about it.
By the NootropicsWork Editorial Team. A plain-English guide, 5 minute read.
Bottom line
Ashwagandha is a plant used in Ayurvedic medicine. One review found it lowered stress scores versus a dummy pill; another found no clear effect. A sleep review found a small improvement, larger in adults with insomnia. Product makers funded or supplied some key trials. Rare liver injury has been reported; Australia's regulator warns about it.
- In a review of 12 trials with 1,002 adults, ashwagandha lowered stress scores more than a placebo, but certainty was rated low [1].
- A review of 5 trials with 400 adults found a small sleep improvement versus a placebo, more so in adults with insomnia [3].
- Liver injury linked to ashwagandha is rare [7]. Most published cases got better after stopping it, but some were severe [6].
For every study, dose and grade, read our full research summary on Ashwagandha.
What is ashwagandha?
Ashwagandha is an evergreen shrub that grows in parts of India, Africa and the Middle East [7]. Its scientific name is Withania somnifera [9].
People have used it as a medicinal plant for thousands of years, especially in traditional Ayurvedic medicine [7]. Health Canada lists it as an adaptogen, a herbal medicine term for a plant said to help the body resist stress over time [9].
Most supplements contain an extract made from the root, the leaf, or both [7].
What do people use ashwagandha for?
NCCIH, part of the US National Institutes of Health, says ashwagandha supplements are often promoted for stress, sleep, male fertility and sports performance [7].
NCCIH's page, last updated in March 2023, said there was not enough evidence to tell whether ashwagandha helps cognitive function or athletic performance [7].
What does the research show?
Most studies below compared ashwagandha with a placebo, a dummy pill with nothing active in it. A meta-analysis combines the results of many trials.
Does ashwagandha lower stress?
Evidence grade for perceived stress: B, moderate. Why this grade
The evidence is mixed. A 2022 meta-analysis pooled 12 trials of stress and anxiety in 1,002 adults aged 25 to 48 [1]. Compared with a placebo, ashwagandha lowered stress scores [1]. But results varied a lot from trial to trial, and the authors rated the certainty of the evidence low [1].
A 2025 meta-analysis looked only at trials that lasted at least 2 weeks and used at least 250 mg a day [2]. Across six trials, it found no clear effect on how stressed people felt [2]. Cortisol, a stress hormone, fell when it pooled the seven trials that measured it [2].
Does ashwagandha help with sleep?
Evidence grade for sleep quality: B, moderate. Why this grade
A 2021 meta-analysis of 5 trials with 400 adults found a small improvement in overall sleep compared with a placebo [3]. The effect was larger in adults diagnosed with insomnia, at 600 mg a day or more, and in trials of 8 weeks or more [3]. Results in people with insomnia may not apply to healthy adults. All five trials were run in India, and one was partly paid for by the product's maker [3].
In a six-week trial, 150 healthy adults with unrefreshing sleep got ashwagandha or a placebo by chance [4]. Neither they nor the researchers knew who got which [4]. The extract's maker, Arjuna Natural, is listed as the study's funder [4]. Self-rated sleep quality rose 72% with ashwagandha and 29% with the placebo [4]. Wrist-worn monitors showed longer total sleep time and less time to fall asleep than with the placebo [4].
Does ashwagandha help build strength with training?
Evidence grade for strength and power output: C, limited. Why this grade
Possibly, but the evidence is weak. A 2026 meta-analysis pooled 3 trials with 161 healthy adults who did weight training [5]. Compared with a placebo, ashwagandha was linked to bigger gains in the most weight lifted once, on bench press and lower-body lifts [5].
Under a stricter math check, both results lost statistical significance, meaning they could have been due to chance [5]. They rated their certainty low [5]. They concluded that current evidence does not show that ashwagandha meaningfully improves training gains [5]. The review reports that all three pooled trials were funded or supplied by ashwagandha makers [5].
Our page on how we grade evidence explains what each grade means.
How much did studies use?
Table: Doses used in studies (not a recommendation)
| What was studied | Doses used in studies | Source |
|---|---|---|
| Stress (dose analysis of pooled trials, low certainty) | Effect on stress scores at 300-600 mg a day | [1] |
| Sleep (subgroup analysis of pooled trials) | Larger effects at 600 mg a day or more, over 8 weeks or longer | [3] |
| Sleep (one trial in healthy adults, funded by the extract maker) | 120 mg of a standardized extract once a day for six weeks | [4] |
| Health Canada monograph for licensed products (adults 18 and older) | 2-6 g of dried root, or 2.5-6.5 g of dried root or whole plant, a day, depending on the use | [9] |
The rows cover different products, from extracts to dried root, so the amounts do not compare directly [4][9]. These are amounts used in research or set out for product licensing, not advice for anyone. Talk to a clinician before trying any supplement.
Is ashwagandha safe?
NCCIH says ashwagandha may be safe in the short term, up to 3 months [7]. It says there is not enough information to judge long-term safety [7]. The 2021 sleep review also found that data on serious side effects are limited [3].
NCCIH reports that ashwagandha products may cause drowsiness, stomach upset, diarrhea and vomiting [7]. Health Canada requires licensed products to carry a label caution about drowsiness for people who drive or use machines [9]. Australia's medicines regulator, the TGA, has warned that some people get sudden and possibly severe gut symptoms [10].
Liver injury is the main safety concern. LiverTox, an NIH liver-safety reference, says ashwagandha has been linked to cases of liver injury [8]. NCCIH describes these cases as rare [7].
A 2026 review of 25 published patients found that liver injury usually appeared after weeks of use [6]. Most patients recovered after stopping and receiving supportive care, usually over weeks to months [6]. One person needed a liver transplant [6]. Three people who already had cirrhosis, a badly scarred liver, died [6].
In a July 2026 alert, the TGA said liver injury cases are still being reported [10]. Since 2024, it has had 4 more reports of possible liver injury [10]. All 4 people recovered after stopping [10].
NCCIH reports that ashwagandha might interact with some medicines [7]. These include medicines for diabetes, blood pressure and thyroid hormone, plus sedatives, anti-seizure medicines and medicines that lower the immune response [7].
If you take any of these medicines, talk to your doctor or pharmacist before combining them with ashwagandha.
Who should be careful with ashwagandha?
- People who are pregnant or breastfeeding. NCCIH says ashwagandha should be avoided during pregnancy and not used while breastfeeding [7]. Health Canada requires labels to tell people to ask a health care provider first [9].
- People with current or past liver disease. The TGA advises that people who have or have had liver problems avoid it [10].
- People with thyroid or autoimmune conditions, or who are about to have surgery. NCCIH does not recommend ashwagandha for these groups [7].
- People with hormone-sensitive prostate cancer. NCCIH says they should avoid it [7].
Want the full picture?
The full research summary grades five outcomes, including endurance and memory. It adds thyroid reports, interaction details and legal status in five countries. Read Ashwagandha: full research summary.
Grades for the outcomes on this page, from the Ashwagandha research summary. They update when the evidence does.
| Outcome | Grade | Basis | Modifiers | Rationale |
|---|---|---|---|---|
| Perceived stress | B Moderate | Meta-analysis with high heterogeneity (I2 = 83.1%, low certainty); A not met because one meta-analysis found no significant effect on the Perceived Stress Scale | Short-term onlySubjective outcome only | Why B grade for Perceived stress: explainedApproved of the Perceived stress grade |
| Sleep quality | B Moderate | Meta-analysis with high heterogeneity (5 RCTs, I2 = 62%) plus 1 large RCT (n = 150) | Short-term only | Why B grade for Sleep quality: explainedApproved of the Sleep quality grade |
| Strength and power output | C Limited | The rubric default to the lower grade: >=2 RCTs with mostly consistent results (3 pooled RCTs) meet the literal B condition, but certainty is low, the estimates are fragile and no preregistered independent RCT is positive | Industry-fundedShort-term only | Why C grade for Strength and power output: explainedApproved of the Strength and power output grade |
References
- Akhgarjand C, Asoudeh F, Bagheri A, et al. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022.
- Albalawi AA. Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis. Nutr Health. 2025.
- Cheah KL, Norhayati MN, Husniati Yaacob L, et al. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One. 2021.
- Deshpande A, Irani N, Balkrishnan R, et al. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020.
- Lee JC, Heo AS. Adjunctive Ashwagandha (Withania somnifera) Supplementation and Resistance-Training Adaptations in Healthy Adults: A Systematic Review and Random-Effects Meta-Analysis of Muscular Strength, Chest Circumference, and Body Composition. Nutrients. 2026.
- McIntyre D, Nguyen P, Kim Y, et al. Ashwagandha (Withania somnifera)-Associated Liver Injury: A Scoping Review of Clinical Characteristics and Safety Considerations. Cureus. 2026.
- National Center for Complementary and Integrative Health (NIH). Ashwagandha: Usefulness and Safety. 2023-03.
- LiverTox, NIDDK (NIH). Ashwagandha. Updated December 3, 2024.
- Health Canada. Natural Health Products Ingredients Database monograph: Ashwagandha - Withania somnifera. Updated February 28, 2025.
- Therapeutic Goods Administration (Australian Government). Herbal preparations containing Withania somnifera (Withania, Ashwagandha): safety alert. Updated July 7, 2026.